Motor activation in multiple system atrophy and Parkinson disease: A PET study
Identifieur interne : 001D31 ( Main/Exploration ); précédent : 001D30; suivant : 001D32Motor activation in multiple system atrophy and Parkinson disease: A PET study
Auteurs : P. Payoux [France] ; C. Brefel-Courbon [France] ; F. Ory-Magne [France] ; W. Regragui [France] ; C. Thalamas [France] ; S. Balduyck [France] ; F. Durif [France] ; J. P. Azulay [France] ; F. Tison [France] ; O. Blin [France] ; J. P. Esquerre [France] ; O. Rascol [France]Source :
- Neurology [ 0028-3878 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background: Multiple system atrophy (MSA) is an atypical parkinsonian syndrome including cerebellar impairment and poor response to levodopa. We assessed right hand motor activation in patients with MSA before and after an acute levodopa challenge in comparison with patients with PD and healthy volunteers (HVs). Methods: Eighteen patients with MSA, 8 patients with PD, and 10 age-matched HVs were included. Regional cerebral blood flow measurements with H215O PET were performed at rest and during a right hand movement. Statistical parametric mapping was used to analyze motor vs rest in OFF and ON conditions and the effect of levodopa on motor activation. Results: Before levodopa, patients with MSA activated most known cerebral motor areas. Compared with HVs, patients with MSA exhibited less bilateral cerebellar activation and greater left superior parietal activation. They also had less bilateral cerebellar and greater supplementary motor and left superior parietal activation than patients with PD. Conversely, patients with PD had greater activation than HVs in the right cerebellum and less in the supplementary motor cortex. After levodopa, patients with MSA exhibited reduced activation in anterior cingulate, whereas patients with PD had greater activation in the right cerebellum. Conclusion: Patients with MSA and patients with PD recruited different motor networks. Patients with PD preferentially activated cerebellar pathways, possibly to compensate for basal ganglia dysfunction. This was not observed in patients with MSA, probably because of cerebellar dysfunction; other frontoparietal cortical areas were recruited.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000514
- to stream PascalFrancis, to step Curation: 000E43
- to stream PascalFrancis, to step Checkpoint: 000476
- to stream Main, to step Merge: 001E63
- to stream Main, to step Curation: 001D31
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Motor activation in multiple system atrophy and Parkinson disease: A PET study</title><author><name sortKey="Payoux, P" sort="Payoux, P" uniqKey="Payoux P" first="P." last="Payoux">P. Payoux</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm Imagerie cérébrale et handicaps neurologiques UMR 825</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Universiré de Toulouse UPS, Imagerie cérébrale et handicaps neurologiques UMR 825, CHU Purpan</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Brefel Courbon, C" sort="Brefel Courbon, C" uniqKey="Brefel Courbon C" first="C." last="Brefel-Courbon">C. Brefel-Courbon</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm Imagerie cérébrale et handicaps neurologiques UMR 825</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Universiré de Toulouse UPS, Imagerie cérébrale et handicaps neurologiques UMR 825, CHU Purpan</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Ory Magne, F" sort="Ory Magne, F" uniqKey="Ory Magne F" first="F." last="Ory-Magne">F. Ory-Magne</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm Imagerie cérébrale et handicaps neurologiques UMR 825</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Universiré de Toulouse UPS, Imagerie cérébrale et handicaps neurologiques UMR 825, CHU Purpan</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Regragui, W" sort="Regragui, W" uniqKey="Regragui W" first="W." last="Regragui">W. Regragui</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm Imagerie cérébrale et handicaps neurologiques UMR 825</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Universiré de Toulouse UPS, Imagerie cérébrale et handicaps neurologiques UMR 825, CHU Purpan</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Thalamas, C" sort="Thalamas, C" uniqKey="Thalamas C" first="C." last="Thalamas">C. Thalamas</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Clinical Investigation Center of Toulouse</s1><s3>FRA</s3><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Clinical Investigation Center of Toulouse</wicri:noRegion><wicri:noRegion>Clinical Investigation Center of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Balduyck, S" sort="Balduyck, S" uniqKey="Balduyck S" first="S." last="Balduyck">S. Balduyck</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm Imagerie cérébrale et handicaps neurologiques UMR 825</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Durif, F" sort="Durif, F" uniqKey="Durif F" first="F." last="Durif">F. Durif</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>University Hospital of Clermont Ferrand</s1><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Clermont Ferrand</wicri:noRegion><wicri:noRegion>University Hospital of Clermont Ferrand</wicri:noRegion></affiliation></author><author><name sortKey="Azulay, J P" sort="Azulay, J P" uniqKey="Azulay J" first="J. P." last="Azulay">J. P. Azulay</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>University Hospital of Marseille</s1><s3>FRA</s3><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Marseille</wicri:noRegion><wicri:noRegion>University Hospital of Marseille</wicri:noRegion></affiliation></author><author><name sortKey="Tison, F" sort="Tison, F" uniqKey="Tison F" first="F." last="Tison">F. Tison</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>University Hospital of Bordeaux</s1><s2>Pessac</s2><s3>FRA</s3><sZ>9 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>University Hospital of Bordeaux</wicri:noRegion><wicri:noRegion>University Hospital of Bordeaux</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Center for Rare Diseases Multi Systemic Atrophy</s1><s2>Bordeaux-Toulouse</s2><s3>FRA</s3><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Bordeaux-Toulouse</wicri:noRegion><wicri:noRegion>Center for Rare Diseases Multi Systemic Atrophy</wicri:noRegion><wicri:noRegion>Center for Rare Diseases Multi Systemic Atrophy</wicri:noRegion></affiliation></author><author><name sortKey="Blin, O" sort="Blin, O" uniqKey="Blin O" first="O." last="Blin">O. Blin</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Clinical Investigation Center of Toulouse</s1><s3>FRA</s3><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Clinical Investigation Center of Toulouse</wicri:noRegion><wicri:noRegion>Clinical Investigation Center of Toulouse</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>University Hospital of Marseille</s1><s3>FRA</s3><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Marseille</wicri:noRegion><wicri:noRegion>University Hospital of Marseille</wicri:noRegion></affiliation></author><author><name sortKey="Esquerre, J P" sort="Esquerre, J P" uniqKey="Esquerre J" first="J. P." last="Esquerre">J. P. Esquerre</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm Imagerie cérébrale et handicaps neurologiques UMR 825</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Universiré de Toulouse UPS, Imagerie cérébrale et handicaps neurologiques UMR 825, CHU Purpan</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O." last="Rascol">O. Rascol</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Center for Rare Diseases Multi Systemic Atrophy</s1><s2>Bordeaux-Toulouse</s2><s3>FRA</s3><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Bordeaux-Toulouse</wicri:noRegion><wicri:noRegion>Center for Rare Diseases Multi Systemic Atrophy</wicri:noRegion><wicri:noRegion>Center for Rare Diseases Multi Systemic Atrophy</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0473877</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0473877 INIST</idno><idno type="RBID">Pascal:10-0473877</idno><idno type="wicri:Area/PascalFrancis/Corpus">000514</idno><idno type="wicri:Area/PascalFrancis/Curation">000E43</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000476</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000476</idno><idno type="wicri:doubleKey">0028-3878:2010:Payoux P:motor:activation:in</idno><idno type="wicri:Area/Main/Merge">001E63</idno><idno type="wicri:Area/Main/Curation">001D31</idno><idno type="wicri:Area/Main/Exploration">001D31</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Motor activation in multiple system atrophy and Parkinson disease: A PET study</title><author><name sortKey="Payoux, P" sort="Payoux, P" uniqKey="Payoux P" first="P." last="Payoux">P. Payoux</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm Imagerie cérébrale et handicaps neurologiques UMR 825</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Universiré de Toulouse UPS, Imagerie cérébrale et handicaps neurologiques UMR 825, CHU Purpan</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Brefel Courbon, C" sort="Brefel Courbon, C" uniqKey="Brefel Courbon C" first="C." last="Brefel-Courbon">C. Brefel-Courbon</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm Imagerie cérébrale et handicaps neurologiques UMR 825</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Universiré de Toulouse UPS, Imagerie cérébrale et handicaps neurologiques UMR 825, CHU Purpan</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Ory Magne, F" sort="Ory Magne, F" uniqKey="Ory Magne F" first="F." last="Ory-Magne">F. Ory-Magne</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm Imagerie cérébrale et handicaps neurologiques UMR 825</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Universiré de Toulouse UPS, Imagerie cérébrale et handicaps neurologiques UMR 825, CHU Purpan</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Regragui, W" sort="Regragui, W" uniqKey="Regragui W" first="W." last="Regragui">W. Regragui</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm Imagerie cérébrale et handicaps neurologiques UMR 825</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Universiré de Toulouse UPS, Imagerie cérébrale et handicaps neurologiques UMR 825, CHU Purpan</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Thalamas, C" sort="Thalamas, C" uniqKey="Thalamas C" first="C." last="Thalamas">C. Thalamas</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Clinical Investigation Center of Toulouse</s1><s3>FRA</s3><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Clinical Investigation Center of Toulouse</wicri:noRegion><wicri:noRegion>Clinical Investigation Center of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Balduyck, S" sort="Balduyck, S" uniqKey="Balduyck S" first="S." last="Balduyck">S. Balduyck</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm Imagerie cérébrale et handicaps neurologiques UMR 825</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Durif, F" sort="Durif, F" uniqKey="Durif F" first="F." last="Durif">F. Durif</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>University Hospital of Clermont Ferrand</s1><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Clermont Ferrand</wicri:noRegion><wicri:noRegion>University Hospital of Clermont Ferrand</wicri:noRegion></affiliation></author><author><name sortKey="Azulay, J P" sort="Azulay, J P" uniqKey="Azulay J" first="J. P." last="Azulay">J. P. Azulay</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>University Hospital of Marseille</s1><s3>FRA</s3><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Marseille</wicri:noRegion><wicri:noRegion>University Hospital of Marseille</wicri:noRegion></affiliation></author><author><name sortKey="Tison, F" sort="Tison, F" uniqKey="Tison F" first="F." last="Tison">F. Tison</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>University Hospital of Bordeaux</s1><s2>Pessac</s2><s3>FRA</s3><sZ>9 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>University Hospital of Bordeaux</wicri:noRegion><wicri:noRegion>University Hospital of Bordeaux</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Center for Rare Diseases Multi Systemic Atrophy</s1><s2>Bordeaux-Toulouse</s2><s3>FRA</s3><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Bordeaux-Toulouse</wicri:noRegion><wicri:noRegion>Center for Rare Diseases Multi Systemic Atrophy</wicri:noRegion><wicri:noRegion>Center for Rare Diseases Multi Systemic Atrophy</wicri:noRegion></affiliation></author><author><name sortKey="Blin, O" sort="Blin, O" uniqKey="Blin O" first="O." last="Blin">O. Blin</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Clinical Investigation Center of Toulouse</s1><s3>FRA</s3><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Clinical Investigation Center of Toulouse</wicri:noRegion><wicri:noRegion>Clinical Investigation Center of Toulouse</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>University Hospital of Marseille</s1><s3>FRA</s3><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Marseille</wicri:noRegion><wicri:noRegion>University Hospital of Marseille</wicri:noRegion></affiliation></author><author><name sortKey="Esquerre, J P" sort="Esquerre, J P" uniqKey="Esquerre J" first="J. P." last="Esquerre">J. P. Esquerre</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm Imagerie cérébrale et handicaps neurologiques UMR 825</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Universiré de Toulouse UPS, Imagerie cérébrale et handicaps neurologiques UMR 825, CHU Purpan</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O." last="Rascol">O. Rascol</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Center for Rare Diseases Multi Systemic Atrophy</s1><s2>Bordeaux-Toulouse</s2><s3>FRA</s3><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Bordeaux-Toulouse</wicri:noRegion><wicri:noRegion>Center for Rare Diseases Multi Systemic Atrophy</wicri:noRegion><wicri:noRegion>Center for Rare Diseases Multi Systemic Atrophy</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Emission tomography</term><term>Multiple system atrophy</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Positron emission tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Atrophie multisystématisée</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Tomoscintigraphie</term><term>Tomographie par émission de positons</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Multiple system atrophy (MSA) is an atypical parkinsonian syndrome including cerebellar impairment and poor response to levodopa. We assessed right hand motor activation in patients with MSA before and after an acute levodopa challenge in comparison with patients with PD and healthy volunteers (HVs). Methods: Eighteen patients with MSA, 8 patients with PD, and 10 age-matched HVs were included. Regional cerebral blood flow measurements with H<sub>2</sub><sup>15</sup>O PET were performed at rest and during a right hand movement. Statistical parametric mapping was used to analyze motor vs rest in OFF and ON conditions and the effect of levodopa on motor activation. Results: Before levodopa, patients with MSA activated most known cerebral motor areas. Compared with HVs, patients with MSA exhibited less bilateral cerebellar activation and greater left superior parietal activation. They also had less bilateral cerebellar and greater supplementary motor and left superior parietal activation than patients with PD. Conversely, patients with PD had greater activation than HVs in the right cerebellum and less in the supplementary motor cortex. After levodopa, patients with MSA exhibited reduced activation in anterior cingulate, whereas patients with PD had greater activation in the right cerebellum. Conclusion: Patients with MSA and patients with PD recruited different motor networks. Patients with PD preferentially activated cerebellar pathways, possibly to compensate for basal ganglia dysfunction. This was not observed in patients with MSA, probably because of cerebellar dysfunction; other frontoparietal cortical areas were recruited.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li></region><settlement><li>Toulouse</li></settlement></list><tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Payoux, P" sort="Payoux, P" uniqKey="Payoux P" first="P." last="Payoux">P. Payoux</name></region><name sortKey="Azulay, J P" sort="Azulay, J P" uniqKey="Azulay J" first="J. P." last="Azulay">J. P. Azulay</name><name sortKey="Balduyck, S" sort="Balduyck, S" uniqKey="Balduyck S" first="S." last="Balduyck">S. Balduyck</name><name sortKey="Blin, O" sort="Blin, O" uniqKey="Blin O" first="O." last="Blin">O. Blin</name><name sortKey="Blin, O" sort="Blin, O" uniqKey="Blin O" first="O." last="Blin">O. Blin</name><name sortKey="Brefel Courbon, C" sort="Brefel Courbon, C" uniqKey="Brefel Courbon C" first="C." last="Brefel-Courbon">C. Brefel-Courbon</name><name sortKey="Brefel Courbon, C" sort="Brefel Courbon, C" uniqKey="Brefel Courbon C" first="C." last="Brefel-Courbon">C. Brefel-Courbon</name><name sortKey="Brefel Courbon, C" sort="Brefel Courbon, C" uniqKey="Brefel Courbon C" first="C." last="Brefel-Courbon">C. Brefel-Courbon</name><name sortKey="Durif, F" sort="Durif, F" uniqKey="Durif F" first="F." last="Durif">F. Durif</name><name sortKey="Esquerre, J P" sort="Esquerre, J P" uniqKey="Esquerre J" first="J. P." last="Esquerre">J. P. Esquerre</name><name sortKey="Esquerre, J P" sort="Esquerre, J P" uniqKey="Esquerre J" first="J. P." last="Esquerre">J. P. Esquerre</name><name sortKey="Esquerre, J P" sort="Esquerre, J P" uniqKey="Esquerre J" first="J. P." last="Esquerre">J. P. Esquerre</name><name sortKey="Ory Magne, F" sort="Ory Magne, F" uniqKey="Ory Magne F" first="F." last="Ory-Magne">F. Ory-Magne</name><name sortKey="Ory Magne, F" sort="Ory Magne, F" uniqKey="Ory Magne F" first="F." last="Ory-Magne">F. Ory-Magne</name><name sortKey="Ory Magne, F" sort="Ory Magne, F" uniqKey="Ory Magne F" first="F." last="Ory-Magne">F. Ory-Magne</name><name sortKey="Payoux, P" sort="Payoux, P" uniqKey="Payoux P" first="P." last="Payoux">P. Payoux</name><name sortKey="Payoux, P" sort="Payoux, P" uniqKey="Payoux P" first="P." last="Payoux">P. Payoux</name><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O." last="Rascol">O. Rascol</name><name sortKey="Regragui, W" sort="Regragui, W" uniqKey="Regragui W" first="W." last="Regragui">W. Regragui</name><name sortKey="Regragui, W" sort="Regragui, W" uniqKey="Regragui W" first="W." last="Regragui">W. Regragui</name><name sortKey="Regragui, W" sort="Regragui, W" uniqKey="Regragui W" first="W." last="Regragui">W. Regragui</name><name sortKey="Thalamas, C" sort="Thalamas, C" uniqKey="Thalamas C" first="C." last="Thalamas">C. Thalamas</name><name sortKey="Tison, F" sort="Tison, F" uniqKey="Tison F" first="F." last="Tison">F. Tison</name><name sortKey="Tison, F" sort="Tison, F" uniqKey="Tison F" first="F." last="Tison">F. Tison</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D31 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001D31 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:10-0473877
|texte= Motor activation in multiple system atrophy and Parkinson disease: A PET study
}}
| This area was generated with Dilib version V0.6.29. |  |